Revista Hospital Clínico Universidad de Chile

Publicaciones WOS 2023 del Hospital Clínico U. de Chile

2024-08-09

We present the summaries of WoS published in 2023 made by our academics in order to account for part of the research carried out in our Clinical Hospital.

Metabolismo de la vitamina D y su papel en la enfermedad de Alzheimer

Fernanda Avila U. — 2024-08-09

Alzheimer disease (AD) is a type of dementia that affects memory, thinking and behavior. Meanwhile, mild cognitive impairment (MCI) is the transitional period between normal aging and dementia, and is the best predictor of future dementia, with an accelerated rate of progression to AD. Amyloid β peptide (Aβ) deposition in AD is due to an imbalance in the production/clearance rate. Vitamin D is a multipurpose secosteroid hormone classically associated with calcium homeostasis, bone formation, and maintenance. However, currently know that vitamin D is a neurosteroid affecting brain development and function; implications for neurological and psychiatric disorders. Many studies have linked low plasma levels of vitamin D with a high prevalence of MCI and AD. Vitamin D acts through its specific nuclear receptor (VDR), which is a transcription factor that binds to the Vitamin D Response Element in the genome. Aβ peptide is transported across the blood brain barrier by LRP1 and P-gp as efflux transporters and RAGE as influx transporter. Numerous evidence indicates that vitamin D modulates the clearance of the Aβ peptide through the regulation of LRP1 and P-gp transporters. This evidence supports the importance of vitamin D food fortification policies recently approved in Chile.

Editorial. El Hospital Clínico de la Universidad de Chile se conecta a su territorio

Eduardo Tobar A. — 2024-08-09

No abstract available

Caracterización de los eventos adversos notificados en pacientes hospitalizados en unidades críticas y básicas de un hospital universitario en Chile

Silvana Villaleiva C. — 2024-08-09

Aim: To characterize the AEs reported in hospitalized patients. Material and methods: An observational, descriptive study. Incidents reported during the year 2021 were analyzed, selecting adverse and sentinel events that occurred in general wards and critical care units, sociodemographic (sex, age) and clinics information (type of AE, working hour, place of occurrence) of affected patients. Results: The adverse events reported in the period were 1.319, 5,4% in 18.075 discharges. In the areas to be analyzed, 989 incidents were reported in 746 patients, 85.9% adverse events and 14,1% to sentinel events; 71,5% affected critical units, 60% affected males. Patient harm occurred in 75% of the cases. The age range most affected in basic units is over 80 years and in critical units in the range of 45-64 years. The main events reported are pressure injuries, 69,1% of all reported events, mainly affecting critically ill patients with rates of 80,8%, followed by self-withdrawals devices 7,6%, followed by medication error 6%. The profession that notifies the most is nursing, 59,4% were informed before the notification to the family. Conclusions: Our results show a greater occurrence of AE in critical areas, consistent with the literature, under-reporting from the physicians and infection control area.

Test radiológico

Vicente Salinas A. — 2024-08-09

No abstract available

Resultado

Vicente Salinas A. — 2024-08-09

No abstract available

Guía de manejo inicial de las lesiones por extravasación

Pablo Meneses R. — 2024-08-09

No abstract available